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biopharmaceutical manufacturing

The entire offering for biopharmaceutical manufacturing

Monitor critical parameters of bioprocesses to secure batch release even in challenging conditions

In biopharmaceutical manufacturing, moving from small scale process development to commercial manufacturing is a challenge. Scale-up brings additional complexity due to a higher level of automation and control. Both quality and process parameters need to be monitored and controlled in real-time to meet product quality specifications, GMP compliance and productivity requirements. We work with you to find the best ways to keep your biopharmaceutical manufacturing process under control.


matching instruments

to user requirements - perfectly engineered, right first time


What you can do

Monitoring the right biopharmaceutical manufacturing process conditions is of the utmost importance when it comes to ensuring consistent batches.
Measurement devices are used to control the critical process parameters, making sure that the cells are growing and the desired protein is produced.

  • Bioreactor and foam level measurement and control

  • Protein separation in chromatography skids

  • Analytical measurement in both laboratory and manufacturing

  • Field instruments for easy calibration

  • Entire instrumentation designed according to the ASME BPE standard

Learn how to standardize your instrumentation

  • bioprocess overview ©Endress+Hauser

    Bioprocess overview

  • fermentation process ©Endress+Hauser

    Fermentation process

  • chromatography process ©Endress+Hauser

    Chromatography process

  • virus filtration process ©Endress+Hauser

    Virus filtration process

  • concentration process ©Endress+Hauser

    Concentration process


Keeping conditions in bioreactors under control

Fermentation is a very complex and sensitive bio-process with a high demand on long-term stability and accuracy. Aseptic conditions must be ensured strictly over the whole biopharmaceutical manufacturing process. To fulfill these requirements consistent measurement is necessary:

  • redundant pH and DO measurement

  • temperature control

  • head space and foam level

  • feed flow control

  • pressure control

fermentation process

Get the most out of your chromatography skid

Chromatography is used to separate the target protein from the complex mixture of the fermentation broth by different interactions with the immobile phase. pH and conductivity define the conditions of the separation process. The target protein is detected by a UV sensor.

  • pH and conductivity measurement

  • UV process photometer

  • Flow control

  • Overpressure and over-temperature protection


Ensure stable inline pH measurement during fermentation

pH is a critical control parameter in a bioreactor. Each cell line has its own optimum pH range for efficient cell growth and protein expression. From laboratory to large scale manufacturing, consistent and reliable data is required. Using the same digital technology over all scales for the pH loops, provides maximum safety and allows an innovative calibration philosophy in the laboratory.

ph measurement

Meet the expert

Nobody knows the challenges within the Life Sciences Industry better than you. Endress+Hauser specialists have years of experience within this industry and understand your biopharmaceutical manufacturing processes and requirements. They are specialists for best matching measuring devices to application needs. It positions them to help you achieve your goals. They are the people for process automation. Meet Klaus Köhler, one of these people.

  • Klaus Köhler, Global Industry Manager for live sciences industry


Streamline your projects for the biopharmaceutical manufacturing process together with our employees, like Klaus Köhler. They provide both a complete range in instrumentation and profound industry expertise to find the best solution for your needs.

80 %

reduction of instrument type diversity

2 months

faster time to market


changes of instruments, thanks to right-first-time specification

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